In Central America and Florida remaining populations are threatened with habitat loss or exploitation, e.g., in Guancaste in Costa Rica, El Salvador, Florida Keys. As with G. officinale, both the timber and medicinal resin are of commercial use and have been traded for several centuries. Tropical semi-deciduous and dry forests, which represent the main habitats of Guaiacum sanctum are among the most threatened ecosystems in the Americas and globally (Miles et al. 2006). Habitat loss of G. sanctum is mainly due to deforestation associated with increasing human populations, conversion of forest to human-managed areas, and increasing fragmentation of the remaining forest area (López‐Toledo et al. 2011, Miles et al. 2006). For Mexico, analyses of the geographic distribution suggested that their habitat is highly fragmented. It is likely that small, isolated populations close to the margins of the species’ distributions are likely to be particularly vulnerable to the negative demographic and genetic effects of forest fragmentation. Although, it still exists an international trade, this has diminished noticeably. At the moment, Mexico is the only exporter of Guaiacum sanctum timber and it is only logged at Campeche state in the Yucatan Peninsula at two localities. These two forest communities fulfill with CITES requirements. The species is used locally for timber but at low levels and this is not a long term threat to the species (López-Toledo et al. 2008). The illegal trade of this species is also rare, with only a small amount being confiscated from Yucatan in 2008. Hence, logging and over harvesting is currently considered a low threat to the species.